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Drug tests are required in many scenarios. You need to pass one before employment while random tests are mostly provided by employers. You may be asked to take a drug test during probation, DUI charges, and child custody. If your are doubtful, it could cost you your job, your family, your freedom. This is why users look for effective ways to beat drug tests.

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Niacin vitamin B3 is promoted for rapidly clearing the body of drugs of abuse, such as cocaine and cannabis, and is alleged to interfere with urine drug screening. We present 4 cases of such novel use associated with ificant adverse effects.

Two cases had isolated skin manifestations, whereas the other 2 presented with life-threatening manifestations, including nausea, vomiting, dizziness, hepatotoxicity, metabolic acidosis, and hypoglycemia evolving into hyperglycemia. One patient also had profound neutrophilia and QT C -interval prolongation. All patients improved after cessation of the drug use and supportive treatment. Health care providers should be aware of these potential adverse effects of niacin and of the misguided use of this vitamin by patients seeking to interfere with urine drug screening.

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RSS Link Copy. Full text links Cite Display options Display options. Abstract Niacin vitamin B3 is promoted for rapidly clearing the body of drugs of abuse, such as cocaine and cannabis, and is alleged to interfere with urine drug screening.

Comment in Consequences of attempts to mask urine drug screens. Heard K, Mendoza CD. Heard K, et al. Ann Emerg Med. Epub May 9. PMID: No abstract available.

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Leung K, et al. Hepatol Commun. Beating the urine drug test - a case report on niacin toxicity. Fayyaz B, et al.

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Acute liver failure secondary to niacin toxicity. Ellsworth MA, et al. Case Rep Pediatr.

Epub Feb Pharmacologically-induced metabolic acidosis: a review. Liamis G, et al.

Drug Saf. Publication types Case Reports Actions. Adolescent Actions. Adult Actions. Female Actions. Humans Actions. Male Actions.

Substances Vitamin B Complex Actions. Niacin Actions.

Medical MedlinePlus Health Information. Full text links [x] Elsevier Science. Copy Download.